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Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

This unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields, come together to provide a clear and comprehensive description of gene delivery, gene therapy and genetic pharmacology.This educational introduction to the main gene transfer vectors and selected therapeutic applications provides the background material needed to further explore the subject as well as relevant research literature. It will thus be invaluable to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide, or develop a gene therapy strategy. Furthermore, the textbook's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

ART DESCRIPTION: A cluster of concentric circles fills the image foreground: rings of dark gray and white against a beige background. Some of the circles are also marked with horizontal and vertical stripes in dark tan and green-gray shades. This Amanti Art canvas art print was created by Flora Kouta and printed by Amanti Art in Madison WI. The canvas is stretched by hand and finished with a float frame. Individually made using traditional custom framing techniques, it has the quality you would expect from your local frame shop. Because of our attention to detail and focus on artistry, architects, interior designers, and homeowners alike choose this framed canvas artwork to create beautiful living spaces. Color: Sylvie Maple.

The 800 series nutating disc flow meters by FILL-RITE are designed to be used to measure diesel, gasoline, kerosene, B20 and E15. Rugged construction, easy to read numbers and the flexibility of horizontal or vertical installations are just three features of these superior meters. Plus, all can be field calibrated for improved accuracy. The 807CL model is a 3 digit liter mechanical meter with no additional accessories. Material: Aluminum.

The DEWALT Combilaser Self Leveling 5-Spot Beam/Horizontal Line Laser Level projects five bright spot beams for precise plumb and horizontal point transfer. Accurate to 1/8 in. at 100 ft., this laser also features a rear-projecting horizontal line which aids in additional leveling applications. It self-levels when within 4° of plane and the beam has an indoor visibility of 100 ft. The range of this handy leveling instrument can be extended to 165 ft. with a separately sold DEWALT laser detector.

The 900 series nutating discl flow meters by FILL-RITE are designed to used to measure diesel, gasoline, kerosene, B20 and E15. Rugged construction, easy to read numbers and the flexibility of horizontal or vertical installations are just 3 features of these superior meters. Plus, all can be field calibrated for improved accuracy. The 901C model is a 4 digit gallon mechanical meter with no additional accessories.

The DUROMAX XP20HP is our largest and most powerful single cylinder engine we offer. This 500cc 4-stroke OHV powerhouse is suitable for multiple heavy-duty applications including go karts, pressure washers, trailer mounted-mobile carwashes, log splitters, roto tillers- cultivators and water/trash transfer pumps. This engine is equipped with convenient features like a large 1.35 Gal. gas tank for longer runtimes, an E-Z pull recoil starter to start the engine with ease and EPA and CARB approved for safe mandated use.

The 800 series nutating disc flow meters by FILL-RITE are designed to use to measure diesel, gasoline, kerosene, B20, and E15. Rugged construction, easy to read numbers, and the flexibility of horizontal or vertical installations are just three features of these superior meters. Plus, all can be field calibrated for improved accuracy. The 807C model is a 3 digit gallon mechanical meter with no additional accessories.

Advances in genetics have begun to deliver on their promise of new and improved approaches to the prevention and treatment of human disease, including the gene-based therapeutics. The international sports community has begun to recognize the potential harmful use of gene transfer technology by athletes. The task of monitoring and controlling sports doping must be a truly cooperative effort, involving the cooperation of a range of local, national, and international organizations. There are very serious broad social and ethical issues at stake that relate to our definition of sports and its role in our society, as well as the social and ethical principles that are challenged or breached through sport doping, determining which forms of performance enhancement – in sport or any other realm of human activity – are acceptable, and what makes the enhancement of sport performance different from enhancement in other areas of human activity (e.g., cosmetic surgery, mood and learning enhancement through drugs, and drug-based “treatment of physical and intellectual changes in normal aging process). This book tackles all these issues and more, serving as the first such focused treatment of this increasingly important topic, which has broad-based implications for science, medicine, sports, and society.

Viral Vectors for Gene Therapy: Methods and Protocols consists of 30 ch- ters detailing the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Chapter cont- butions provide perspective in the use of viral vectors for applications in the brain and in the central nervous system. Viral Vectors for Gene Therapy: Methods and Protocols contains step-by-step methods for successful rep- cation of experimental procedures, and should prove useful for both experienced investigators and newcomers in the field, including those beginning graduate study or undergoing postdoctoral training. The “Notes” section contained in each chapter provides valuable troublesho- ing guides to help develop working protocols for your laboratory. With Viral Vectors for Gene Therapy: Methods and Protocols, it has been my intent to develop a comprehensive collection of modern molecular methods for the construction, development, and use of viral vectors for gene transfer and gene therapy. I would like to thank the many chapter authors for their contributions. They are all experts in various aspects of viral vectors, and I appreciate their efforts and hard work in developing comprehensive chapters. As editor, it has been a privilege to preview the development of Viral Vectors for Gene Therapy: Methods and Protocols, and to acquire insight into the various methodological approaches from the many different contri- tors.

The 900 series nutating disc flow meters by FILL-RITE are designed to be used to measure diesel, gasoline, kerosene, B20 and E15. Rugged construction, easy to read numbers and the flexibility of horizontal or vertical installations are just 3 features of these superior meters. Plus, all can be field calibrated for improved accuracy. The 901C1.5 model is a 4-digit gallon mechanical meter with no additional accessories. Material: Aluminum.

The 800 series nutating disc flow meters by FILL-RITE are designed to be used to measure diesel, gasoline, kerosene, B20 and E15. Rugged construction, easy to read numbers, and the flexibility of horizontal or vertical installations are just 3 features of these superior meters. Plus, all can be field calibrated for improved accuracy. The 807C1 model is a 3 digit gallon mechanical meter with no additional accessories. Material: Aluminum.

Viral Vectors for Gene Therapy: Methods and Protocols consists of 30 ch- ters detailing the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Chapter cont- butions provide perspective in the use of viral vectors for applications in the brain and in the central nervous system. Viral Vectors for Gene Therapy: Methods and Protocols contains step-by-step methods for successful rep- cation of experimental procedures, and should prove useful for both experienced investigators and newcomers in the field, including those beginning graduate study or undergoing postdoctoral training. The “Notes” section contained in each chapter provides valuable troublesho- ing guides to help develop working protocols for your laboratory. With Viral Vectors for Gene Therapy: Methods and Protocols, it has been my intent to develop a comprehensive collection of modern molecular methods for the construction, development, and use of viral vectors for gene transfer and gene therapy. I would like to thank the many chapter authors for their contributions. They are all experts in various aspects of viral vectors, and I appreciate their efforts and hard work in developing comprehensive chapters. As editor, it has been a privilege to preview the development of Viral Vectors for Gene Therapy: Methods and Protocols, and to acquire insight into the various methodological approaches from the many different contri- tors.

The Duromax XP7HP is the premium performing engine available from Duromax. It features a 208cc 4-Stroke Overhead Valve design Engine that has a E-Z Pull Recoil Start. It can cranks out 9.7 ft./lbs. of Torque. This Engine can handle everything you can throw at it, whether being used for log splitters, water transfer pumps or custom go-karts, the Duromax line of engines will deliver power when you need it.

The DUROMAX XP18HPX is our largest and most powerful Dual Fuel engine. This 439cc 4-stroke OHV powerhouse is suitable for multiple heavy-duty applications including go karts, pressure washers, trailer-mounted mobile carwashes, log splitters, rototillers/cultivators, and water/trash transfer pumps. The XP18HPX comes equipped with convenient features such as a large 1.4 Gal. gas tank., a propane hookup for flexibility and longer runtimes, an electric keyed start, and an E-Z pull recoil starter. This engine is EPA and CARB approved for safe mandated use.

The DUROMAX XP20HPE is our largest and most powerful single cylinder engine we offer. This 500cc 4-stroke OHV powerhouse is suitable for multiple heavy-duty applications including go karts, pressure washers, trailer mounted-mobile carwashes, log splitters, roto tillers- cultivators and water/trash transfer pumps. This engine is equipped with convenient features like a large 1.35 Gal. gas tank for longer runtimes, an electric start feature for easier startups, an E-Z pull recoil starter for startup flexibility and EPA and CARB approved for safe mandated use.

The DEWALT(R) 120 ft. 3-Spot Laser level features 3 bright, self-leveling beams which provide accurate plumb and horizontal point transfer. This Spot Laser Level is great during the early stages of constructions with steel framing, lighting and plumb joists, just to name a few. The rugged over-molded housing on this level provides protection in case of drops or run-ins with other tools.

The XtremepowerUS gasoline engine water pump is designed for efficient water transfer, boasting a capacity of up to 158 gallons per minute (GPM) and featuring large 2 in. intake/discharge ports capable of accommodating soft solids up to 1/4 in. Dia. Powered by a robust 6.5HP horizontal single-cylinder 4-stroke OHV engine, this pump is equipped with EPA phase III compliant technology, ensuring reliable performance. Its versatility extends to various applications such as draining pools, emptying flooded basements, pumping out trenches, filling or emptying water storage tanks, irrigating fields and hosing down construction sites. The inclusion of a durable cast iron volute and impeller, along with high-quality silicon carbide seals, guarantees a long service life. Furthermore, the pump features heat dissipation holes on its side to prevent overheating during continuous use, thereby prolonging its operational lifespan. Additionally, the package includes a 25 ft. discharge hose, a 12 ft. suction hose, a filter, an oil funnel, a spark plug socket, hose clamps, fittings and adapters, with the recommendation to use sealing tape when connecting hoses to the water pump to prevent leakage.